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Treatment the pediatric rhinitis by CD(Cyclodextrin) garlic suspension
Abstract
Objective: The goal of this study was to identify the effectiveness of vasoconstriction, anti-inflammation and antibiosis of CD garlic powder and to apply this to the treatment of pediatric rhinitis. Materials and Methods: Experimental study objects: Materials: CD garlic powder: we used the CD garlic powder made at Pyongyang Taeun Pharmaceutical Factory. Strain: Escherichia coli O111(ATCC No.25922), Staphylococcus aureus 209-P(ATCC No.25923) purchased from National Microbiological Institute (Pyongyang, DPR Korea). Media: Peptone broth medium, Agar medium. Experimental animals. Toad (20-25g), Spragues-Dawley rats(120-180g), Rabbits(over 1.5Kg) These animals were selected without distinction of sex. (Purchased from the experimental animal shed at Pyongyang University of medical sciences). Clinical study objects: We selected 110 pediatric patients less than 14 years old with chronic rhinitis, who have no complications and no serious deviation of nasal septum. Result: CD garlic powder has less irritation and has remarkable actions of anti-inflammation, antibiosis and vasoconstriction. The treatment effect of CD garlic suspension was 87.5% when it was swabbed nasal cavity mucosa.
References
Onuora Chidinma et al., Therapeutic Effects of Garlic-A Review, Scientific Journal of Biology & Life Sciences,1(1): 2019 1~5.
Colín González AL, Santana RA, Silva Islas CA, Chánez Cárdenas ME, Santamaría A (2012) The antioxidant mechanisms underlying the aged garlic extract and S allylcysteine-induced protection, Oxidative Medicine and Cellular Longevity 10: 1155.
Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, et al. (2009) Garlic: empiricism or science? Nat Prod Commun 4(12): 1785-1796.
Tsao SM, Yin MC (2001) In vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oil. J Med Microbiol 50(7): 646-649.
Nervi C (2006) Garlic Biochemistry: Effect on human health, Università degli Studi di Torino. Nutrition and Food Research 51(11): 1386-1397.
Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM, et al. (2012) Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized double-blind placebo-controlled nutrition intervention. Clin Nutr 31 (3): 337-344.
Tariq Abdullah et al., A Strategic Call to Utilize EchinaceaGarlic in Flu-Cold Seasons Journal of The National Medical Association, Vol. 92, No. 1, January 2000, 48-51
Mehrbod, P. et al., Assessment of direct immunofluorescence assay in detection of antiviral effect of garlic extract on influenza virus, African Journal of Microbiology Research, Vol. 7(21), pp. 2608-2612, 21 May, 2013.
Josling P., Preventing the common cold with a garlic supplement: a double-blind placebo-controlled survey. Adv Ther 18(4) ,2001: 189-193.
Hahn G., Garlic: the science and therapeutic application of Allium sativum L and related species (2nd edn). Baltimore Williams and Wilkins, 1996, pp. 1-24.
Allen DB. et al. No growth suppression in children treated with the maximum recommended dose of fluticasone propionate aqueous nasal spray for one year. Allergy Asthma Proc. 2002; 23; 407~413.
G.K.Scadding et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis(Revised Edition 2017; First edition 2007), Clin Exp Allergy. 2017; 47;856~889.
Meltzer EO et al. Mometasone furoate nasal spray plus oxymetazoline nasal spray: short-term efficacy and safety in seasonal allergic rhinitis. Am J Rhinol Allergy. 2013; 27; 102~108.
F. Musshoff, Naphazoline intoxication in a child—a clinical and forensic toxicological case, Forensic Science International 134 (2003) 234–237.
DOI: https://doi.org/10.37591/rrjom.v12i2.2807
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