Prevalence and Antibiogram Profile of Uropathogens Isolated from Symptomatic and Asymptomatic Female Patients with Urinary Tract Infections and its Associated Risk Factors: Focus on Cephalosporin

Authors

  • Varsha Rani Gajamer PhD Scholar, Department of Microbiology, Sikkim University, Gangtok ,Sikkim, India
  • Ashish Kr. Singh PhD Scholar, Department of Microbiology, Sikkim University, Gangtok ,Sikkim, India
  • Nilu Pradhan PhD Scholar, Department of Microbiology, Sikkim University, Gangtok ,Sikkim, India
  • Jyotsna Kapil Professor, Department of Microbiology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
  • Arunabha Sarkar Senior Consultant Microbiologist, Neotia Get Well Health Care Centre & Head, Department of Microbiology, North Bengal Medical College, Siliguri, Darjeeling, West Bengal, India
  • Hare Krishna Tiwari Associate Professor and Head, Department of Microbiology, Sikkim University, Gangtok, Sikkim, India,

DOI:

https://doi.org/10.37591/rrjomst.v7i1.211

Abstract

Urinary tract infections (UTIs) are common among women. Here, the present study probes the prevalence of urinary tract infection (UTI), assess the adequacy of empirical therapy, susceptibility of antibiotics and resistance pattern of bacteria responsible for UTI and its associated risk factors. A total of 1309 urine samples were collected from UTI suspected female patients of tertiary care hospitals between the ages of 18-49. Moreover, a total of 207 urine samples were collected randomly from female population of same group without the symptoms of UTI by direct interview using comprehensive pre-structured English questionnaire. The standard microbiological techniques were used for isolation and identification of the samples. Antibiotic susceptibility test was performed by disk diffusion and agar dilution method. Relative risk analyses were carried out using online software ‘‘MEDCALC’’. The total prevalence of UTI among females was 29.44%, with prevalence rate of asymptomatic UTI and symptomatic UTI as 4.34% and 25.1% respectively. Additionally, we show that Escherichia coli as predominant uropathogen (74.3%) followed by Klebsiella pneumoniae (20.1%), Pseudomonas aeruginosa (2.4%) and Proteus mirabilis. Imipenem and piperacillin/tazobactam were more effective. MIC value of most of the uropathogen against cephalosporin group of antibiotics is on rise with MIC value of most of the uropathogen as 256 uglml. The main risk factor associated with asymptomatic UTI was frequency of sexual activity and the quantity of water consumption with a relative risk factor of 1.3913 and 1.0531 respectively. Increasing resistance against commonly used antibiotics is a matter of great concern for treating physician and health policy makers.

 

Keywords: Asymptomatic UTI, females, risk factors

 

Cite this Article

Varsha Rani Gajamer, Ashish Kr. Singh, Nilu Pradhan et al. Prevalence and Antibiogram Profile of Uropathogens Isolated from Symptomatic and Asymptomatic Female Patients with Urinary Tract Infections and its Associated Risk Factors: Focus on Cephalosporin. Research & Reviews: Journal of Medical Science and Technology. 2018; 7(1):
32–41p.

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Published

2018-05-02

Issue

Vol. 7 No. 1 (2018)

Section

Research Article

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