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Synergistic and Antagonistic Effects of Azo-Schiff Base with Some Antibiotics on Gram-Positive Bacterial Isolates

Salimah Aboulqasim Ali, Najat Ramadan Elzawi, Abdelhamid Mohamed Elyassiry


Antibacterial resistance has brought an urgent need to find a solution to the problem of antibacterial resistance and increase the effectiveness of antibiotics. Therefore, our current study was aimed to test the three concentrations viz., 0.5 mg/ml, 5 mg/ml and 50 mg/ml of Azo-Schiff base against Gram-positive bacteria—Bacillus cereus, Micrococcus lutes, Staphylococcus aureus—to compare the effects of Schiff base alone or along with antibiotics on the viability of bacteria. Our results showed no antibacterial activity of Schiff base (L2) against three bacterial strains except S. aureus at concentration of 50 mg/ml. Synergistic effects of Schiff base was observed against B. cereus with only antibiotics CN10, but antagonistic effects was observed at all concentrations with all antibiotics.


Resistance, Schiff base, synergistic effect, antagonistic effect, antibacterial

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