A Review for Metastasis (Silent Killer) to Both Soft and Hard Tissue of Oral Cavity

Authors

  • Meenakshi .
  • Garima Sharma
  • Reena Pabri
  • Ghata Savoriya
  • Sajan Vaish
  • Manju Devi

Keywords:

Metastasis, cancer, oral cavity, primary tumour, malignant

Abstract

Metastasis is defined by the spread of a tumour to sites that are physically discontinuous with the primary tumour, and unequivocally marks a tumour as malignant. One of the illnesses that poses the greatest risk to human life is cancer. Patients with cancer may experience metastasis years or even decades, after the main tumour was diagnosed, making the metastatic process considerably more complicated and the disease more lethal. Cancer from other body locations may spread to the mouth cavity. There are many tumours which metastasize to oral cavity; among them, most common are lung, breast, kidney and bone malignancies. The oral soft tissues were less frequently impacted than the jawbones, especially the mandible. Because the oral cavity is not a preferred target, metastatic lesions are uncommon in this site. Thus, the prognosis of cancer and life expectancy are significantly influenced by metastasis.

References

Kumar GS and BS Manjunatha. Metastatic tumors to the jaws and oral cavity. J Oral Maxillofac Pathol. 2013; 17(1): 71–5.

Rao RS, Patil S, Sanketh DS, et al. Metastatic Tumors of the Oral Cavity. J Contemp Dent Pract. 2014; 15(2): 263–71.

Hirshberg A, Shnaiderman‐Shapiro A, Kaplan I, et al. Metastatic tumours to the oral cavity‐Pathogenesis and analysis of 673 cases. Oral Oncol. 2008; 44(8): 743–52.

Batson OV. The function of the vertebral veins and their role in the spread of metastases. Ann Surg. 1940; 112(1): 138–49.

Hirshberg A, Berger R, Allon I, et al. Metastatic tumors to the jaws and mouth. Head Neck Pathol. 2014; 8(4): 463–74.

Nawale KK, Vyas M, Kane S, et al. Metastatic tumors in the jaw bones: A retrospective clinicopathological study of 12 cases at Tertiary Cancer Center. J Oral Maxillofac Pathol. 2016; 20(2): 252–5.

Hirshberg A, Leibovich P, Buchner A. Metastatic tumors to the jawbones: Analysis of 390 cases. J Oral Pathol Med. 1994; 23(8): 337–41.

Hirshberg A, Berger R, Allon I, et al. Metastatic tumors to the jaws and mouth. Head Neck Pathol. 2014; 8(4): 463–74.

Hirshberg A, Leibovich P, Buchner A. Metastases to the oral mucosa: Analysis of 157 cases. J Oral Pathol Med. 1993; 22(9): 385–90.

Otenio CC, Fonseca I, Martins MF, et al. Expression of IL-1b, IL-6, TNF-a, and iNOS in pregnant women with periodontal disease. Genet Mol Res. 2012; 11(4): 4468–78.

Bickel M, Axtelius B, Solioz C, et al. Cytokine gene expression in chronic periodontitis. J Clin Periodontol. 2001; 28(9): 840–7.

Lim SY, Kim SA, Ahn SG, et al. Metastatic tumours to the jaws and oral soft tissues: a retrospective analysis of 41 Korean patients. Int J Oral Maxillofac Surg. 2006; 35(5): 412–5.

Irani S. Metastasis to the oral soft tissues: A review of 412 cases. J Int Soc Prevent Communit Dent. 2016; 6(5): 393–401.

Irani S. Metastasis to the Jawbones: A review of 453 cases. J Int Soc Prevent Communit Dent. 2017; 7(2): 71–81.

Baldawa P, Shirol P, Alur J, et al. Metastasis: To and fro. J Oral Maxillofac Pathol. 2017; 21(3): 463–4.

Barnes L. Metastases to the head and neck: An overview. Head Neck Pathol. 2009; 3(3): 217–24.

Virk MS, Lieberman JR. Tumor metastasis to bone. Arthritis Res Ther. 2007. 9 Suppl 1(Suppl 1): S5.

Wang Y. Breast cancer metastasis driven by ErbB2 and 14‐3‐3zeta: A division of labor. Cell Adh Migr. 2010; 4(1): 7–9.

Antunes AA, Antunes AP. Gnathic bone metastasis: a retrospective study of 10 cases. Braz J Otorhinolaryngol. 2008; 74(4): 561–5.

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Published

2023-09-05

Issue

Vol. 12 No. 1 (2023)

Section

Review Article

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