Brain GST Inhibition, An Additional Mode of Action Following Beta-Cyfluthrin Intoxication in Albino Rat

Abstract

The aim of the study was to reveal the neurotoxic effect of an orally administered beta-cyfluthrin, a type-II pyrethroid in albino rats on the basis of activity of brain GST (Glutathione-s-transferase), AChE (acetylcholinesterase) and of total proteins level at different doses 35.48 and 5.06, 2.53, 1.68, 1.27 mg/kg body weight, for acute (1 day) and sub-acute (7, 14, 21 and 28 days) treatments respectively. Results reveal that beta-cyfluthrin administration inhibits AChE activity and GST activity, however, no significant effect in total brain proteins could be observed. Affinity towards the hydrophobicity of xenobiotic substance (experimental compound) may lead to an inhibitory mechanism of both AChE and GST levels. Further, imbalance in the neurotransmitter level and alterations in the detoxification mechanism in brain is suggestive of additional mode of action of beta-cyfluthrin other than AChE inhibition.

Keywords: Glutathione-s-transferase (GST), acetylcholinesterase (AChE), beta-cyfluthrin, detoxification, albino rats